Contribution à l'étude de la pollinisation du cacaoyer. Le cacaoyer est-il insuffisamment pollinisé ?

Analyse bibliographique critique d'un grand nombre de travaux relatifs à l'aspect quantitatif de la pollinisation du cacaoyer et évaluation de la contribution de la pollinisation au rendement potentiel du cacaoye

Decreased Sialidase Activity in Alveolar Macrophages of Guinea Pigs Exposed to Coal Mine Dust

International audienceThe origin of immune dysfunctions that are observed in pneumoconiotic miners still remains unknown. There is evidence that the carbohydrate moiety of membrane glycoconjugates is of primary importance in many functions of immunocompetent cells. The glycosylation, and especially the sialylation level of membrane components of various lymphocyte and macrophage subsets, vary depending on the state of cellular differentiation and activation. Sialidases, which may regulate the amount of sialic acids exposed on the cell membrane, can thus be considered as immunoregulatory enzymes. In this report, the sialidase activity has been measured in alveolar macrophages (AM) and in cell-free bronchoalveolar lavage fluid (BALF) from guinea pigs exposed for 4 months to coal mine dust at a concentration of 300 mg/m3. The samples were collected by bronchoalveolar lavage 2 months after cessation of exposure. The sialidase activity in the cell-free fluid and in the purified alveolar macrophages showed a 10-fold decrease (p < 0.001). Kinetic parameters of the enzyme such as K(m) and optimum pH did not change. This changed activity was specific for sialidase, as two other lysosomal glycosidases, beta-galactosidase and N-acetylglucosaminidase, showed unchanged activities. These results suggest the possibility that, by inducing a decreased sialidase activity, exposure to coal mine dust may lead to a modified expression of AM membrane-associated sialic acids giving rise to altered immune functions (i. e., phagocytosis, antigen processing response to cytokines, etc.)

Current-current correlations in hybrid superconducting and normal metal multiterminal structures

We consider a hybrid system consisting of two normal metal leads weakly connected to a superconductor. Current-current correlations of the normal leads are studied in the tunneling limit at subgap voltages and temperatures. We find that only two processes contribute to the cross-correlation: the crossed Andreev reflection (emission of electrons in different leads) and the elastic cotunneling. Both processes are possible due to the finite size of the Cooper pair. Noise measurements can thus be used to probe directly the superconducting wave function without the drawbacks appearing in average current measurements where the current is dominated by direct Andreev reflection processes. By tuning the voltages it is possible to change the sign of the cross correlation. Quantitative predictions are presented both in the diffusive and ballistic regimes.Comment: 7 pages, 2 Figure